Publications in scientific journals: 2022

2022

Akingbuwa WA, Hammerschlag AR, Bartels M, Middeldorp CM. Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders. Journal of the American Academy of Child & Adolescent Psychiatry. 2022;61(2):227-242, Open Access
DOI: 10.1016/j.jaac.2021.03.020
Supplementary Materials (zip file)

Allegrini AG, Beijsterveldt CEM van, Boomsma DI, Rimfeld K, Pingault JB, Plomin R, Bartels M, Nivard MG. Developmental co-occurrence of psychopathology dimensions in childhood. JCPP Advances. 2022;2(3):e12100, Open Access
DOI: 10.1002/jcv2.12100
Supplementary Materials (zip file) 

Alrouh H, Bergen E van, Zeeuw EL de, Dolan CV, Boomsma DI. Intergenerational transmission of body mass index and associations with educational attainment. BMC Public Health. 2022;22(890), Open Access
DOI: 10.1186/s12889-022-13270-1
Supplementary Materials (zip file)

Barbu MC, Huider F, Campbell A, Amador C, Adams MJ, Lynall ME, Howard DM, Walker RM, Morris SW, Dongen J van, Porteous DJ, Evans KL, Bullmore E, Willemsen G, Boomsma DI, Whalley HC, McIntosh AM. Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system. Molecular Psychiatry. 2022;27(3):1647-1657, Open Access.
DOI: 10.1038/s41380-021-01412-7
Supplementary Materials (zip file)

Bignardi G, Chamberlain R, Kevenaar ST, Tamimy Z, Boomsma DI. On the etiology of aesthetic chills: a behavioral genetic study. Nature Scientific Reports 2022;12(3247), Open Access
DOI: 10.1038/s41598-022-07161-z

Brouwer RM, Klein M, Grasby KL, Schnack HG, Jahanshad N, Teeuw J, Heslenfeld DJ, Jansen PR, Hottenga JJ, Milaneschi Y, Ent D van ‘t, the IMAGEN Consortium, Boomsma DI, Penninx BWJH, Wright MJ, Medland SE, Franke B, Thompson PM, Hulshoff Pol HE, many others. Genetic variants associated with longitudinal changes in brain structure across the lifespan. Nature Neuroscience. 2022;25(4):421-432
DOI: 10.1038/s41593-022-01042-4
Supplementary Materials (zip file)

Coomans EM, Tomassen J, Ossenkoppele R, Golla SSV, Hollander M den, Collij LE, Weltings E, Landen S van der, Wolters EE, Windhorst AD, Barkhof F, Geus EJC de, Scheltens P, Visser PJ, Berckel BNM van, Braber A den. Genetically identical twins show comparable tau PET load and spatial distribution. Brain. 2022;145(10):3571-3581, Open Access
DOI: 10.1093/brain/awac004
Supplementary Materials (zip file)

COVID-19 Host Genetics Initiative, includes Hottenga JJ, Bartels M, Geus EJC de, Nivard MG on behalf of the NTR. A first update on mapping the human genetic architecture of COVID-19. Nature. 2022;608:E1-E10, Open Access
DOI: 10.1038/s41586-022-04826-7
Supplementary Materials (zip file)

Dediu D, Jennings EM, Ent D van't, Moisik SR, Di Pisa G, Schulze J, Geus EJC de, den Braber A, Dolan CV, Boomsma DI. The heritability of vocal tract structures estimated from structural MRI in a large cohort of Dutch twins. Human Genetics. 2022;141(12):1905-1923, Open Access
DOI: 10.1007/s00439-022-02469-2
Supplementary Materials (zip file)

Demange PA, Hottenga JJ, Abdellaoui A, Moen Eilertsen E, Malanchini M, Domingue BW, Armstrong-Carter E, Zeeuw EL de, Rimfeld K, Boomsma DI, Bergen E van, Breen G, Nivard MG, Cheesman R. Estimating effects of parents’ cognitive and non-cognitive skills on offspring education using polygenic scores. Nature Communications. 2022;13:4801
DOI: 10.1038/s41467-022-32003-x
Supplementary Materials (zip file)

Dima D, Modabbernia A, Papachristou E, Doucet GE, Agartz I, Aghajani M, Akudjedu TN, Albajes‐Eizagirre A, Alnæs D, Alpert KI, Boomsma DI, Brouwer RM, Crone EA, Geus EJC de, Braber A den, Heslenfeld DJ, Hulshoff Pol HE, Martin NG, Oosterlaan J, Swagerman SC, Ent D van't, Wolf DH, Worker A, Wright MJ, Yang K, Yoncheva Y, Zanetti MV, Ziegler GC, Thompson PM, Frangou S, Karolinska Schizophrenia Project (KaSP), many others. Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years. Human Brain Mapping. 2022;43(1):452-469, Open Access
DOI: 10.1002/hbm.25320
Supplementary Materials (zip file)

Doust C, Fontanillas P, Eising E, 23andMe Research Team, Quantitative Trait Working Group of the GenLang Consortium, Boomsma DI, Zeeuw EL de, Hottenga JJ, Bergen E van, Bates TC, Fisher SE, Luciano M, many others. Discovery of 42 genome-wide significant loci associated with dyslexia. Nature Genetics. 2022;54(11):1621-1629, Open Access
DOI: 10.1038/s41588-022-01192-y
Supplementary Materials (zip file)

Eising E, Mirza-Schreiber N, Zeeuw EL de, Wang CA, Truong DT, Hottenga JJ, Boomsma DI, Bergen E van, Whitehouse AJO, Willcutt EG, St Pourcain B, Francks C, Fisher SE, many others. Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people. PNAS. 2022;119(35):e2202764119, Open Access
DOI: 10.1073/pnas.2202764119
Supplementary Materials (zip file)

Frangou S, Modabbernia A, Williams SCR, Papachristou E, Doucet GE, Agartz I, Aghajani M, Akudjedu TN, Albajes‐Eizagirre A, Alnæs D, Boomsma DI, Geus EJC de, Braber A den, Hulshoff Pol HE, Kahn RS, Martin NG, Swagerman SC, Ent D van 't, Wolf DH, Worker A, Wright MJ, Yang K, Yoncheva Y, Zanetti MV, Ziegler GC, Karolinska Schizophrenia Project (KaSP), Thompson PM, Dima D, many others. Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years. Human Brain Mapping. 2022;43(1):431-451, Open Access
DOI: 10.1002/hbm.25364
Supplementary Materials (zip file)

Hagenbeek FA, Dongen J van, Pool R, Harms AC, Roetman PJ, Fanos V, Keulen BJ van, Walker BR, Karu N, Hulshoff Pol HE, Rotteveel J, Finken MJJ, Vermeiren RRJM, Kluft C, Bartels M, Hankemeier T, Boomsma DI. Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children. Metabolites. 2022;12(6):474, Open Access
DOI: 10.3390/metabo12060474
Supplementary Materials (zip file)

Hagenbeek FA, Dongen J van, Pool R, Roetman PJ, Harms AC, Hottenga JJ, Kluft C, Colins OF, Beijsterveldt CEM van, Fanos V, Ehli EA, Hankemeier T, Vermeiren RRJM, Bartels M, Déjean S, Boomsma DI. Integrative Multi-omics Analysis of Childhood Aggressive Behavior. Behavior Genetics. 2022;53(2):101-117, Open Access
DOI: 10.1007/s10519-022-10126-7
Supplementary Materials (zip file)

Hagenbeek FA, Dongen J van, Pool R, Boomsma DI. Twins and omics: the role of twin studies in multi-omics. Chapter in Twin Research for Everyone From Biology to Health, Epigenetics, and Psychology. Edited by A.D. Tarnoki, D.L. Tarnoki, J.R. Harris & N.L. Segal. Academic Press, 2022

Hautakangas H, Winsvold BS, Ruotsalainen SE, Bjornsdottir G, Harder AVE, Boomsma DI, Hottenga JJ, Ligthart L, Penninx BWJH, International Headache Genetics Consortium; HUNT All-in Headache; Danish Blood Donor Study Genomic Cohort, Folkmann Hansen T, Ripatti S, Zwart JA, Palotie A, Pirinen M, many others. Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles. Nature Genetics. 2022;54(2):152-160, Open Access
DOI: 10.1038/s41588-021-00990-0
Supplementary Materials (zip file)

Howe LJ, Nivard MG, Morris TT, Hansen AF, Rasheed H, Zee MD van der, Boomsma DI, Geus EJC de, Kweon H, Social Science Genetic Association Consortium, Within Family Consortium, Bartels M, Koellinger PD, Davey Smith G, Hayward C, Brumpton B, Hemani G, Davies NM, many others. Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects. Nature Genetics. 2022;54(5):581-592, Open Access
DOI: 10.1038/s41588-022-01062-7
Supplementary Materials (zip file)

Hur Y-M, Odintsova VV, Ordoñana JR, Silventoinen K, Willemsen G. Twin family registries worldwide. Chapter in Twin Research for Everyone From Biology to Health, Epigenetics, and Psychology. Edited by A.D. Tarnoki, D.L. Tarnoki, J.R. Harris & N.L. Segal. Academic Press, 2022

Jami ES, Hammerschlag AR, Ip HF, Allegrini AG, Benyamin B, Hagenbeek FA, Hottenga JJ, Beijsterveldt CEM van, Boomsma DI, Williams GM, Ystrøm E, Nivard MG, Bartels M, Middeldorp CM, many others. Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms. Journal of the American Academy of Child & Adolescent Psychiatry. 2022;61(7):934-945, Open Access
DOI: 10.1016/j.jaac.2021.11.035
Supplementary Materials (zip file)

Jonkman TH, Dekkers KF, Slieker RC, Grant CD, Arfan Ikram M, Greevenbroek MMJ van, Franke L, Veldink JH, Boomsma DI, Slagboom PE, BIOS Consortium, Heijmans BT. Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression. Genome Biology. 2022;23:24, Open Access
DOI: 10.1186/s13059-021-02585-8
Supplementary Materials (zip file)

Kamali Z, Keaton JM, Haghjooy Javanmard S, Edwards TL, Snieder H, Vaez A, International Consortium of Blood Pressure, Million Veteran Program, eQTLGen Consortium, BIOS Consortium, Boomsma DI, Geus EJC de, Hottenga JJ, Willemsen G, Dongen J van, Pool R, Jansen R, Penninx BWJH, many others. Large-Scale Multi-Omics Studies Provide New Insights into Blood Pressure Regulation. International Journal of Molecular Sciences. 2022;23(14):7557, Open Access
DOI: 10.3390/ijms23147557
Supplementary Materials (zip file)

Kanoni S, Graham SE, Wang Y, Hottenga JJ, Penninx BWJH, Boomsma DI, Willemsen G, Willer CJ, Assimes TL, Peloso GM, many others. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Genome Biology. 2022;23(1):268, Open Access
DOI: 10.1186/s13059-022-02837-1
Supplementary Materials (zip file)

Klimentidis YC, Newell M, Zee MD van der, Bland VL, May-Wilson S, Arani G, Menni C, Mangino M, Arora A, Raichlen DA, Alexander GE, Wilson JF, Boomsma DI, Hottenga JJ, Geus EJC de, Pirastu N. Genome-wide Association Study of Liking for Several Types of Physical Activity in the UK Biobank and Two Replication Cohorts. Medicine & Science in Sports & Exercise. 2022;54(8):1252-1260
DOI: 10.1249/MSS.0000000000002907

Knigge A, Maas I, Stienstra K, Zeeuw EL de, Boomsma DI. Delayed tracking and inequality of opportunity: Gene-environment interactions in educational attainment. NPJ science of learning. 2022;7(6), Open Access
DOI: 10.1038/s41539-022-00122-1
Supplementary Materials (zip file)

Li-Gao R, Boomsma DI, Dolan CV, Geus EJC de, Denollet J, Kupper N. Genetic and environmental contributions to stability and change in social inhibition across the adolescent and adult life span. Developmental Psychology. 2022;58(8):1585-1599
DOI: 10.1037/dev0001379

Mallard TT, Savage JE, Johnson EC, Huang Y, Edwards AC, Hottenga JJ, Nivard MG, Geus EJC de, Boomsma DI, Agrawal A, Davis LK, Clarke TK, Palmer AA, Sanchez-Roige S, others. Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts. The American Journal of Psychiatry. 2022;179(1):58-70
DOI: 10.1176/appi.ajp.2020.20091390
Supplementary Materials (zip file)

Mitchell BL, Saklatvala JR, Dand N, Hagenbeek FA, Li X, Min JL, Thomas L, Bartels M, Hottenga JJ, Lupton MK, Boomsma DI, Dong X, Hveem K, Løset M, Martin NG, Barker JN, Han J, Smith CH, Rentería ME, Simpson MA. Genome-wide association meta-analysis identifies 29 new acne susceptibility loci. Nature Communications. 2022;13:702, Open Access
DOI: 10.1038/s41467-022-28252-5
Supplementary Materials (zip file)

Mitchell BL, Diaz-Torres S, Bivol S, Cuellar-Partida G, International Headache Genetics Consortium (Ligthart L, Hottenga JJ, Penninx BWJH, Posthuma D, Boomsma DI, many others), Gerring ZF, Martin NG, Medland SE, Grasby KL, Nyholt DR, Rentería ME. Elucidating the relationship between migraine risk and brain structure using genetic data. Brain. 2022;145(9):3214-3224
DOI: 10.1093/brain/awac105
Supplementary Material (zip file)

Neumann A, Nolte IM, Pappa I, Ahluwalia TS, Pettersson E, Beijsterveldt CEM van, Hammerschlag AR, Helmer Q, Bartels M, Hottenga JJ, Middeldorp CM, Bakermans-Kranenburg MJ, Boomsma DI,  IJzendoorn MH van, Hartman CA, Tiemeier H, many others. A genome-wide association study of total child psychiatric problems scores. PLOS ONE. 2022;17(8): e0273116, Open Access
DOI: 10.1371/journal.pone.0273116
Supplementary Materials (zip file)

Niehues A, Bizzarri D, Reinders MJT, Slagboom PE, Gool AJ van, Akker EB van den, Hoen PAC ’t, BBMRI-NL BIOS consortium, BBMRI-NL Metabolomics Consortium, Jansen R, Boomsma DI, Pool R, Dongen J van, Hottenga JJ, Willemsen G, many others. Metabolomic predictors of phenotypic traits can replace and complement measured clinical variables in population-scale expression profiling studies. BMC Genomics. 2022;23(1):546, Open Access
DOI: 10.1186/s12864-022-08771-7
Supplementary Materials (zip file)

Odintsova VV, Suderman M, Hagenbeek FA, Caramaschi D, Hottenga JJ, Pool R, BIOS Consortium, Dolan CV, Ligthart L, Beijsterveldt CEM van, Willemsen G, Geus EJC de, Beck JJ, Ehli EA, Cuellar-Partida G, Evans DM, Medland SE, Relton CL, Boomsma DI, Dongen J van. DNA methylation in peripheral tissues and left-handedness. Scientific Reports. 2022;12:5606, Open Access
DOI: 10.1038/s41598-022-08998-0
Supplementary Materials (zip file)

Odintsova VV, Willemsen G, Dolan CV, Hottenga JJ, Martin NG, Slagboom PE, Ordoñana JR, Boomsma DI. Establishing a resource for genetic, epidemiological, and biomarker studies: The important role of twin registers. Chapter in Twin Research for Everyone From Biology to Health, Epigenetics, and Psychology. Edited by A.D. Tarnoki, D.L. Tarnoki, J.R. Harris & N.L. Segal. Academic Press, 2022

Okbay A, Wu Y, Wang N, Jayashankar H, Bennett M, 23andMe Research Team, Abdellaoui A, Hottenga JJ, Willemsen G, Boomsma DI for the Social Science Genetic Association Consortium, Turley P, Visscher PM, Beauchamp JP, Benjamin DJ, Young AI, many others. Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals. Nature Genetics. 2022;54(4):437-449
DOI: 10.1038/s41588-022-01016-z
Supplementary Materials (zip file)

Pasman J, Demange PA, Guloksuz S, Willemsen AHM, Abdellaoui A, Have M ten, Hottenga JJ, Boomsma DI, Geus EJC de, Bartels M, Graaf R de, Verweij KJH, Smit DJA, Nivard MG, Vink JM. Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status. Behavior Genetics. 2022;52(2):92-107, Open Access
DOI: 10.1007/s10519-021-10094-4
Supplementary Materials (zip file)

Price KM, Wigg KG, Eising E, Feng Y, Blokland K, Wilkinson M, Kerr EN, Guger SL, Quantitative Trait Working Group of the GenLang Consortium, Boomsma DI, Zeeuw E de, Hottenga JJ, Bergen E van, Fisher SE, Lovett MW, Strug LJ, Barr CL. Hypothesis-driven genome-wide association studies provide novel insights into genetics of reading disabilities. Translational Psychiatry. 2022;12(495), Open Access
DOI: 10.1038/s41398-022-02250-z
Supplementary Materials (zip file)

Rajula HSR, Manchia M, Agarwal K, Akingbuwa WA, Allegrini AG, Diemer E, Doering S, Haan E, Jami ES, Karhunen V, Leone M, Schellhas L, Thompson A, van den Berg SM, Bergen SE, Kuja-Halkola R, Hammerschlag AR, Järvelin MR, Leval A, Lichtenstein P, Lundstrom S, Mauri M, Munafò MR, Myers D, Plomin R, Rimfeld K, Tiemeier H, Ystrom E, Fanos V, Bartels M, Middeldorp CM. Overview of CAPICE-Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe-an EU Marie Skłodowska-Curie International Training Network. European Child & Adolescent Psychiatry. 2022;31(5):829-839, Open Access
DOI: 10.1007/s00787-020-01713-2

Ramdas S, Judd J, Graham SE, Hottenga JJ, Boomsma DI, Geus EJC de, Penninx BWJH, Willer CJ, Zhu X, Brown CD, many others. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. American Journal of Human Genetics. 2022;109(8):1366-1387
DOI: 10.1016/j.ajhg.2022.06.012

Saunders GRB, Wang X, Chen F, Boomsma DI, Hottenga JJ, Polderman TJC, Willemsen G, 23andMe Research Team; Biobank Japan Project, Thorgeirsson TE, Liu DJ, Vrieze S, many others. Genetic diversity fuels gene discovery for tobacco and alcohol use. Nature. 2022;612(7941):720-724, Open Access
DOI: 10.1038/s41586-022-05477-4
Supplementary Materials (zip file)

Silventoinen K, Li W, Jelenkovic A, Sund R, Yokoyama Y, Willemsen G, Bartels M, Beijsterveldt CEM van, Martin NG, Medland SE, Plomin R, Llewellyn CH, Fisher A, Boomsma DI, Sørensen TIA, Kaprio J, many others. Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts. International Journal of Obesity. 2022;46(10):1901-1909, Open Access
DOI: 10.1038/s41366-022-01202-3
Supplementary Materials (zip file)

Slob EMA, Longo C, Vijverberg SJH, Beijsterveldt CEM van, Bartels M, Hottenga JJ, Pijnenburg MW, Koppelman GH, Maitland-van der Zee AH, Dolan CV, Boomsma DI. Persistence of parental-reported asthma at early ages: A longitudinal twin study. Pediatric Allergy and Immunology. 2022;33(3):e13762, Open Access
DOI: 10.1111/pai.13762
Supplementary Materials (zip file)

Sønderby IE, Ching CRK, Thomopoulos SI, Meer D van der, Sun D, Villalon-Reina JE, Agartz I, Amunts K, Arango C, Armstrong NJ, Boomsma DI, Hottenga JJ, Hulshoff Pol HE, Ent D van 't, Stefánsson K, Jacquemont S, Thompson PM, Bearden CE, Andreassen OA, many others for the ENIGMA-CNV Working Group, ENIGMA 22q11.2 Deletion Syndrome Working Group. Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs. Human Brain Mapping. 2022;43(1):300-328, Open Access
DOI: 10.1002/hbm.25354

Spek A van der, Karamujić-Čomić H, Pool R, Bot M, Beekman M, Garmaeva S, Arp PP, Henkelman S, Liu J, Couto Alves A, Willemsen G, Grootheest G van, Aubert G, BBMRI Metabolomics Consortium, Ikram MA, Jarvelin MR, Lansdorp P, Uitterlinden AG, Zhernakova A, Slagboom PE, Penninx BWJH, Boomsma DI, Amin N, Duijn CM van. Fat metabolism is associated with telomere length in six population-based studies. Human Molecular Genetics. 2022;31(7):1159-1170
DOI: 10.1093/hmg/ddab281
Supplementary Materials (zip file)

Strom NI, Smit DJA, Silzer T, Iyegbe C, Burton CL, Pool R, Lemire M, Crowley JJ, Hottenga JJ, Ivanov VZ, Larsson H, Lichtenstein P, Magnusson P, Rück C, Schachar RJ, Wu HM, Meier SM, Crosbie J, Arnold PD, Mattheisen M, Boomsma DI, Mataix-Cols D, Cath D. Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals. Translational Psychiatry. 2022;12:479, Open Access
DOI: 10.1038/s41398-022-02248-7
Supplementary Materials (zip file)

Tarnoki AD, Willemsen G, Geus EJC de, Tarnoki DL. Twin studies of cardiorespiratory disease, daily cardiovascular activity and imaging. Chapter in Twin Research for Everyone From Biology to Health, Epigenetics, and Psychology. Edited by A.D. Tarnoki, D.L. Tarnoki, J.R. Harris & N.L. Segal. Academic Press, 2022

Tate AE, Akingbuwa WA, Karlsson R, Hottenga JJ, Pool R, Boman M, Larsson H, Lundström S, Lichtenstein P, Middeldorp CM, Bartels M, Kuja-Halkola R. A genetically informed prediction model for suicidal and aggressive behaviour in teens. Translational Psychiatry. 2022;12:488
DOI: 10.1038/s41398-022-02245-w
Supplementary Materials (zip file)

Teeuw J, Klein M, Roth Mota N, Brouwer RM, Ent D van ‘t, Al-Hassaan Z, Franke B, Boomsma DI, Hulshoff Pol HE. Multivariate Genetic Structure of Externalizing Behavior and Structural Brain Development in a Longitudinal Adolescent Twin Sample. International Journal of Molecular Sciences. 2022;23(6):3176, Open Access
DOI: 10.3390/ijms23063176
Supplementary Materials (zip file)

Tomassen J, Braber A den, Landen SM van der, Konijnenberg E, Teunissen CE, Vermunt L, Geus EJC de, Boomsma DI, Scheltens P, Tijms BM, Visser PJ. Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin study. Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI). 2022;8(1):e12346
DOI: 10.1002/trc2.12346
Supplementary Materials (zip file)

Tomassen J, Braber A den, Lee SJ van der, Reus LM, Konijnenberg E, Carter SF, Yaqub M, Berckel BNM van, Collij LE, Boomsma DI, Geus EJC de, Scheltens P, Herholz K, Tijms BM, Visser PJ. Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer’s disease polygenic risk score. BMC Neurology. 2022;22:484
DOI: 10.1186/s12883-022-02925-6
Supplementary Materials (zip file)

Vlaanderen J, Vermeulen R, Whitaker M, Chadeau-Hyam M, Hottenga JJ, Geus EJC de, Willemsen G, Penninx BWJH, Jansen R, Boomsma DI. Impact of long-term exposure to PM2.5 on peripheral blood gene expression pathways involved in cell signaling and immune response. Environment International. 2022;168:107491
DOI: 10.1016/j.envint.2022.107491
Supplementary Materials (zip file)

Vries LP de, Weijer MP van de, Pelt DHM, Ligthart L, Willemsen G, Boomsma DI, Geus EJC de, Bartels M. Gene-by-Crisis Interaction for Optimism and Meaning in Life: The Effects of the COVID-19 Pandemic. Behavior Genetics. 2022;52(1):13-25, Open Access
DOI: 10.1007/s10519-021-10081-9
Supplementary Materials (zip file)

Vries LP de, Pelt DHM, Ploeg HP van der, Chinapaw MJM, Geus EJC de, Bartels M. The association between well-being and a large variation of accelerometer-assessed physical activity and sedentary behavior measures. Mental Health and Physical Activity. 2022;22:100446, Open Access
DOI: 10.1016/j.mhpa.2022.100446
Supplementary Materials (zip file)

Wang Z, Emmerich A, Pillon NJ, Pool R, Boomsma DI, Willemsen G, Geus EJC de, Milaneschi Y, Penninx BWJH, Thomis MAI, Loos RJF, Hoed M den, many others. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention. Nature Genetics. 2022;54(9):1332-1344, Open Access
DOI: 10.1038/s41588-022-01165-1
Supplementary Materials (zip file)

Weijer MP van de, Pelt DHM, Vries LP de, Huider F, Zee MD van der, Helmer Q, Ligthart L, Willemsen G, Boomsma DI, Geus EJC de, Bartels M. Genetic and environmental influences on quality of life: The COVID-19 pandemic as a natural experiment. Genes, Brain and Behavior. 2022;e12796, Open Access
DOI: 10.1111/gbb.12796
Supplementary Materials (zip file)

Weijer MP van de, Baselmans BML, Hottenga JJ, Dolan CV, Willemsen G, Bartels M. Expanding the environmental scope: an environment-wide association study for mental well-being. Journal of Exposure Science & Environmental Epidemiology. 2022;32(2):195-204, Open Access
DOI: 10.1038/s41370-021-00346-0
Supplementary Materials (zip file)

Weijer MP van de, Vries LP de, Pelt HM, Ligthart L, Willemsen G, Boomsma DI, Geus EJC de, Bartels M. Self-rated health when population health is challenged by the COVID-19 pandemic; a longitudinal study. Social Science & Medicine. 2022;306:115156, Open Access
DOI: 10.1016/j.socscimed.2022.115156
Supplementary Materials (zip file)

Weijer MP van de, Pelt DHM, Beijsterveldt CEM van, Willemsen G, Bartels M. Genetic factors explain a significant part of associations between adolescent well-being and the social environment. European Child & Adolescent Psychiatry. 2022;31(10):1611-1622, Open Access
DOI: 10.1007/s00787-021-01798-3
Supplementary Materials (zip file)

Weijer MP van de, Vries LP de, Bartels M. Happiness and wellbeing: The value and findings from genetic studies. Chapter in Twin Research for Everyone From Biology to Health, Epigenetics, and Psychology. Edited by A.D. Tarnoki, D.L. Tarnoki, J.R. Harris & N.L. Segal. Academic Press, 2022

Wierenga LM, Doucet GE, Dima D, Agartz I, Aghajani M, Akudjedu TN, Albajes-Eizagirre A, Alnæs D, Alpert KI, Andreassen OA, Boomsma DI, Braber A den, Brouwer RM, Buitelaar JK, Ent D van’t, Geus EJC de, Haan L de, Heslenfeld DJ, Heuvel OA van den, Hulshoff Pol HE, Karolinska Schizophrenia Project (KaSP) Consortium, Martin NG, Oosterlaan J, Wolf DH, Wright MJ, Yoncheva YN, Zanetti MV, Ziegler GC, Zubicaray GI de, Thompson PM, Crone EA, Frangou S, Tamnes CK, many others. Greater male than female variability in regional brain structure across the lifespan. Human Brain Mapping. 2022;43(1):470-499, Open Access
DOI: 10.1002/hbm.25204

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Supplementary Materials (zip file)