Publications in scientific journals: 2021
Articles based on NTR research2021
Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J, Beekman M, Ben-Shlomo Y, Geus EJC de, Milaneschi Y, Hottenga JJ, Penninx BWJH, CHARGE Inflammation Working Group, Dongen J van, Willemsen G, Boomsma DI, Slagboom PE, Stathopoulou MG, Tanaka T, Wannamethee SG, Whincup P, Rotter JI, Dehghan A, Boerwinkle E, Psaty BM, Snieder H, Alizadeh BZ, many others. Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci. Human Molecular Genetics. 2021;30(5):393-409, Open Access
DOI: 10.1093/hmg/ddab023
Supplementary Materials (link to HMG website)
Arends RM, Pasman JA, Verweij KJH, Derks EM, Gordon SD, Hickie I, Thomas NS, Aliev F, Zietsch BP, Zee MD van der, Mitchell BL, Martin NG, Dick DM, Gillespie NA, Geus EJC de, Boomsma DI, Schellekens AFA, Vink JM. Associations between the CADM2 gene, substance use, risky sexual behavior, and self‐control: A phenome‐wide association study. Addiction Biology. 2021;26(6):e13015, Open Access
DOI: 10.1111/adb.13015
Supplementary Materials (zip file)
Beck JJ, Pool R, Weijer M van de, Zee MD van der, Baselmans BML, Finnicum CT, Beijsterveldt T van, Christensen K, Martin NG, Plomin R, Nivard MG, Bartels M, Dolan CV, Willemsen G, Geus EJC de, Magnusson PKE, Mbarek H, Ehli EA, Boomsma DI, Hottenga JJ, others. Genetic Meta-Analysis of Twin Birth Weight Shows High Genetic Correlation with Singleton Birth Weight. Human Molecular Genetics. 2021;30(19):1894-1905, Open Access.
DOI: 10.1093/hmg/ddab121
Supplementary Materials (on HMG Website)
Beck JJ, Bruins S, Mbarek H, Davies GE, Boomsma DI. Biology and Genetics of Dizygotic and Monozygotic Twinning. Chapter in Twin and Higher-order Pregnancies. Edited by Khalil, Lewi & Lopriore. Springer Nature, 2021
Bergen E van, Vasalampi K, Torppa M. How Are Practice and Performance Related? Development of Reading From Age 5 to 15. Reading Research Quarterly. 2021;56(3):415-434, Open Access
DOI: 10.1002/rrq.309
Blokland GAM, Grove J, Chen CY, Cotsapas C, Tobet S, Handa R, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Sullivan PF, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Martin NG, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Boomsma DI, Penninx BWJH, Hottenga JJ, Geus EJC de, Willemsen G, Milaneschi Y, Tiemeier H, Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium, iPSYCH, Als TD, Børglum AD, Petryshen TL, Smoller JW, Goldstein JM, many others. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biological Psychiatry. 2021;91(1):102-117
DOI: 10.1016/j.biopsych.2021.02.972
Supplementary Materials (zip file)
Blokland IV van, Lanting P, Ori APS, Vonk JM, Warmerdam RCA, Bartels M, Hottenga JJ, Lifelines COVID-19 cohort study, The COVID-19 Host Genetics Initiative, Washington NL, Geus EJC de, Deelen P, Boezen HM, Franke LH, others. Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility. PLOS ONE. 2021;16(8):e0255402, Open Access
DOI: 10.1371/journal.pone.0255402
Supplementary Materials (zip file)
Boomsma DI, Beijsterveldt CEM van, Odintsova VV, Neale MC, Dolan CV. Genetically Informed Regression Analysis: Application to Aggression Prediction by Inattention and Hyperactivity in Children and Adults. Behavior Genetics. 2021;51(3):250-263, Open Access
DOI: 10.1007/s10519-020-10025-9
Supplementary Material (zip file)
Bos MM, Goulding NJ, Lee MA, Hofman A, Bot M, Pool R, Li-Gao R, Beekman M, Boomsma DI, Heijmans 16, Arfan Ikram M, Jukema JW, Penninx BWJH, Slagboom PE, Willemsen G, Zwinderman AH, Heemst D van, Noordam R, Lawlor DA, others. Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multicohort multivariable regression and Mendelian randomization analyses. BMC Medicine. 2021;19(69), Open Access
DOI: 10.1186/s12916-021-01939-0
Supplementary Materials (zip file)
Brand EC, Klaassen MAY, Gacesa R, Vich Vila A, Ghosh H, Zoete MR de, Boomsma DI, Hoentjen F, Horjus Talabur Horje CS, Meeberg PC van de, Willemsen G, Fu J, Wijmenga C, Wijk F van, Zhernakova A, Oldenburg B, Weersma RK, Dutch TWIN-IBD consortium and the Dutch Initiative on Crohn and Colitis. Healthy cotwins share gut microbiome signatures with their inflammatory bowel disease twins and unrelated patients. Gastroenterology. 2021;160(6):1970-1985, Open Access
DOI: 10.1053/j.gastro.2021.01.030
Brouwer RM, Schutte J, Janssen R, Boomsma DI, Hulshoff Pol HE, Schnack HG. The Speed of Development of Adolescent Brain Age Depends on Sex and Is Genetically Determined. Cerebral Cortex. 2021;31(2):1296-1306, Open Access
DOI: 10.1093/cercor/bhaa296
Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Hottenga JJ, Geus EJC de, Lifelines Cohort Study, Boomsma DI, Slagboom PE, Snieder H, Vrijkotte TGM, Willemsen G, Mohlke KL, Langenberg C, Wheeler E, Morris AP, Barroso I, many others for The Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC). The trans-ancestral genomic architecture of glycemic traits. Nature Genetics. 2021;53(6):840-860
DOI: 10.1038/s41588-021-00852-9
Supplementary Materials (zip file)
Cuellar-Partida G, Tung JY, Eriksson N, Albrecht E, Aliev F, Andreassen OA, Barroso I, Beckmann JS, Boks MP, Boomsma DI, Geus EJC de, Hottenga JJ, Penninx BWJH, Vink JM, Willemsen G, Wright MJ, Xu M, Hua Zhao J, Kraft P, Hinds DA, Lindgren CM, Mägi R, Neale BM, Evans DM, Medland SE, many others. Genome-wide association study identifies 48 common genetic variants associated with handedness. Nature Human Behaviour. 2021;5(1):59-70
DOI: 10.1038/s41562-020-00956-y
Supplementary Materials (zip file)
Demange PA, Malanchini M, Mallard TT, Biroli P, Cox SR, Grotzinger AD, Tucker-Drob EM, Abdellaoui A, Arseneault L, Bergen E van, Boomsma DI, Caspi A, Corcoran DL, Domingue BW, Mullan Harris K, Ip HF, Mitchell C, Moffitt TE, Poulton R, Prinz JA, Sugden K, Wertz J, Williams BS, Zeeuw EL de, Belsky DW, Harden KP, Nivard MG. Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction. Nature Genetics. 2021;53:35-44
DOI: 10.1038/s41588-020-00754-2
Supplementary Materials (zip file)
Dennis J, Sealock J, Levinson RT, Farber-Eger E, Franco J, Fong S, Straub P, Hucks D, Song WL, Linton MF, Fontanillas P, Elson SL, Ruderfer D, Abdellaoui A, Sanchez-Roige S, Palmer AA, Boomsma DI, Cox NJ, Chen G, Mosley JD, Wells QS, Davis LK. Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease. Molecular Psychiatry. 2021;26(8):4254-4264, Open Access
DOI: 10.1038/s41380-019-0614-y
Supplementary Materials (zip file)
Dolan CV, Huijskens RCA, Minică CC, Neale MC, Boomsma DI. Incorporating Polygenic Risk Scores in the ACE Twin Model to Estimate A–C Covariance. Behavior Genetics. 2021;51(3):237-249, Open Access
DOI: 10.1007/s10519-020-10035-7
Supplementary Material
Dongen J van, Hagenbeek FA, Suderman M, Roetman PJ, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty JD, Adams MJ, Ip HF, Jansen R, Baselmans BML, Ligthart L, BIOS Consortium, Davies GE, IJzendoorn MH van, Relton C, Vrijheid M, Sebert S, Järvelin MR, Caspi A, Evans KL, McIntosh AM, Bartels M, Boomsma DI, many others. DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan. Molecular Psychiatry. 2021;26(6):2148-2162, Open Access
DOI: 10.1038/s41380-020-00987-x
Supplementary Materials (zip file)
Dongen J van, Gordon SD, Odintsova VV, McRae AF, Robinson WP, Hall JG, Boomsma DI, Martin NG. Examining the Vanishing Twin Hypothesis of Neural Tube Defects: Application of an Epigenetic Predictor for Monozygotic Twinning. Twin Research and Human Genetics. 2021;24(3):155-159, Open Access
DOI: 10.1017/thg.2021.25
Dongen J van, Gordon SD, McRae AF, Odintsova VV, Mbarek H, Hagenbeek FA, Beijsterveldt CEM van, Hottenga JJ, BIOS Consortium, Genetics of DNA Methylation Consortium, Ehli EA, Geus EJC de, Willemsen G, Bell JT, Mill J, Caspi A, Martin NG, Boomsma DI, many others. Identical twins carry a persistent epigenetic signature of early genome programming. Nature Communications. 2021;12(1):5618, Open Access
DOI: 10.1038/s41467-021-25583-7
Supplementary Materials (zip file)
Dongen J van, Odintsova VV, Boomsma DI. Discordant monozygotic twin studies of epigenetic mechanisms in mental health. Chapter in Translational Epigenetics, Volume 27: Twin and Family Studies of Epigenetics. Edited by Li & Hopper. Academic Press, 2021
Fedko IO, Hottenga JJ , Helmer Q, Mbarek H, Huider F, Amin N, Beulens JW , Bremmer MA , Elders PJ, Galesloot TE, Kiemeney LA, Loo HM van, Picavet HSJ, Rutters F, Spek A van der, Wiel AM van de, Duijn C van, Geus EJC de, Feskens EJM, Hartman CA, Oldehinkel AJ, Smit JH, Verschuren WMM, Penninx BWJH, Boomsma DI, Bot M. Measurement and genetic architecture of lifetime depression in the Netherlands as assessed by LIDAS (Lifetime Depression Assessment Self-report). Psychological Medicine. 2021;51(8):1345-1354, Open Access
DOI: 10.1017/S0033291720000100
Supplementary Materials (zip file)
Forstner AJ, Awasthi S, Wolf C, Maron E, Erhardt A, Czamara D, Eriksson E, Lavebratt C, Allgulander C, Friedrich N, Mbarek H, Milaneschi Y, Geus EJC de, Boomsma DI, Penninx BWJH, Hultman CM, Sullivan PF, Nöthen MM, Woldbye DPD, Mors O, Binder EB, Rück C, Ripke S, Deckert J, Schumacher J, many others. Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression. Molecular Psychiatry. 2021;26(8):4179-4190
DOI: 10.1038/s41380-019-0590-2
Supplementary Materials (zip file)
Garvert L, Baune BT, Berger K, Boomsma DI, Breen G, Greinacher A, Penninx BWJH, Smoller JW, Tiemeier H, Uher R, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Grabe HJ, Auwera S Van der, others. The association between genetically determined ABO blood types and major depressive disorder. Psychiatry Research. 2021;299(113837)
DOI: 10.1016/j.psychres.2021.113837
Supplementary Materials (zip file)
Graham SE, Hottenga JJ, Willemsen G, Boomsma DI, Geus EJC de, Willer CJ and many others for the VA Million Veteran Program. The power of genetic diversity in genome-wide association studies of lipids. Nature. 2021;600(7890):675-679
DOI: 10.1038/s41586-021-04064-3
Supplementary Materials (zip file)
Hart SA, Little C, Bergen E van. Nurture might be nature: cautionary tales and proposed solutions. npj Science of Learning. 2021;6:2, Open Access
DOI: 10.1038/s41539-020-00079-z
Huider F, Milaneschi Y, Zee MD van der, Geus EJC de, Helmer Q, Penninx BWJH, Boomsma DI. Major Depressive Disorder and Lifestyle: Correlated Genetic Effects in Extended Twin Pedigrees. Genes. 2021;12(10):1509, Open Access
DOI: 10.3390/genes12101509
Ingala S, Tomassen J, Collij LE, Prent N, Ent D van 't, Kate M ten, Konijnenberg E, Yaqub M, Scheltens P, Geus EJC de, Teunissen CE, Tijms B, Wink AM, Barkhof F, Berckel BNM van, Visser PJ, Braber A den. Amyloid-driven disruption of default mode network connectivity in cognitively healthy individuals. Brain Communications. 2021;3(4):fcab201, Open Access
DOI: 10.1093/braincomms/fcab201
Ip HF, Laan CM van der, Krapohl EML, Brikell I, Sánchez-Mora C, Hammerschlag AR, Hottenga JJ, Middeldorp CM, Vinkhuyzen AE, Davies GE, Ehli EA, Hagenbeek FA, Zeeuw E de, Beijsterveldt CEM van, Snieder H, Verhulst FC, Amin N, Eaves LJ, Maes HH, Martin NG, Vrijkotte T, Kaprio J, Tiemeier H, Lundström S, Plomin R, Bartels M, Nivard MG, Boomsma DI, many others. Genetic association study of childhood aggression across raters, instruments, and age. Translational Psychiatry. 2021;11:413, Open Access
DOI: 10.1038/s41398-021-01480-x
Supplementary Materials (zip file)
Jami ES, Hammerschlag AR, Bartels M, Middeldorp CM. Parental characteristics and offspring mental health and related outcomes: a systematic review of genetically informative literature. Translational Psychiatry. 2021;11(1):197, Open Access
DOI: 10.1038/s41398-021-01300-2
Jia T, Chu C, Liu Y, Dongen J van, Papastergios E, Armstrong NJ, Bastin ME, Carrillo-Roa T, Braber A den, Harris M, Jansen R, Ent D van’t, Boomsma DI, Deary IJ, Hulshoff Pol H, Ophoff RA, Pausova Z, Sachdev PS, Saykin A, Wright MJ, Thompson PM, Schumann G, Desrivieres S. Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group. Molecular Psychiatry. 2021;26(8):3884-3895, Open Access
DOI: 10.1038/s41380-019-0605-z
Supplementary Materials (zip file)
Johnson BN, Peters HE, Lambalk CB, Dolan CV, Willemsen G, Ligthart L, Mijatovic V, Hottenga JJ, Ehli EA, Boomsma DI. Male microchimerism in females: a quantitative study of twin pedigrees to investigate mechanisms. Human Reproduction. 2021;36(9):2529-2537, Open Access
DOI: 10.1093/humrep/deab170
Kalafati M, Kutmon M, Evelo CT, Kallen CJH van der, Schalkwijk CG, Stehouwer CDA, Blaak EE, Greevenbroek MMJ van, Adriaens M, BIOS (Biobank-based Integrative Omics Study) Consortium, Boomsma DI, Pool R, Dongen J van, Hottenga JJ, many others. An interferon-related signature characterizes the whole blood transcriptome profile of insulin-resistant individuals—the CODAM study. Genes and Nutrition. 2021;16(1):22
DOI: 10.1186/s12263-021-00702-7
Supplementary Materials (zip file)
Kevenaar ST, Zondervan-Zwijnenburg MAJ, Blok E, Schmengler H, Fakkel MT, Zeeuw EL de, Bergen E van, Onland-Moret NC, Peeters M, Hillegers MHJ, Boomsma DI, Oldehinkel AJ. Bayesian evidence synthesis in case of multi-cohort datasets: An illustration by multi-informant differences in self-control. Developmental Cognitive Neuroscience. 2021;47, Open Access
DOI: 10.1016/j.dcn.2020.100904
Supplementary Material (zip file)
Konijnenberg E, Tomassen J, Braber A den, Kate M ten, Yaqub M, Mulder SD, Nivard MG, Vanderstichele H, Lammertsma AA, Teunissen CE, Berckel BNM van, Boomsma DI, Scheltens P, Tijms BM, Visser PJ. Onset of Preclinical Alzheimer Disease in Monozygotic Twins. Annals of Neurology. 2021;89(5):987-1000, Open Access
DOI: 10.1002/ana.26048
Supplementary Material (zip file)
Kreeke JA van de, Nguyen HT, Konijnenberg E, Tomassen J, Braber A den, Kate M ten, Yaqub M, Berckel B van, Lammertsma AA, Boomsma DI, Tan SH, Visser PJ, Verbraak FD. Longitudinal retinal layer changes in preclinical Alzheimer’s disease. Acta Ophthalmologica. 2021;99(5):538-544, Open Access
DOI: 10.1111/aos.14640
Supplementary Materials (zip file)
Kurilshikov A, Medina-Gomez C, Bacigalupe R, Radjabzadeh D, Wang J, Demirkan A, Le Roy CI, Raygoza Garay JA, Finnicum CT, Liu X, Zhernakova DV, Boomsma DI, Davies GE, IJzerman RG, Willemsen G, Geus EJC de, Franke A, Lerch MM, Franke L, Sanna S, D’Amato M, Pedersen O, Paterson AD, Kraaij R, Raes J, Zhernakova A, many others. Large-scale association analyses identify host factors influencing human gut microbiome composition. Nature Genetics. 2021;53:156-165
DOI: 10.1038/s41588-020-00763-1
Supplementary Material (zip file)
Laan CM van der, Morosoli‑García JJ, van de Weijer SGA, Colodro‑Conde L on behalf of the ACTION Consortium, Lupton MK, Mitchell BL, McAloney K, Parker R, Burns JM, Hickie IB, Pool R, Hottenga JJ, Martin NG, Medland SE, Nivard MG, Boomsma DI. Continuity of Genetic Risk for Aggressive Behavior Across the Life‑Course. Behavior Genetics. 2021;51(5):592-606
DOI: 10.1007/s10519-021-10076-6
Supplementary Files (zip file)
Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, Willemsen G, Geus EJC de, Boomsma DI, Froguel P, Kaakinen MA, Lyssenko V, Watanabe RM, Ingelsson E, Florez JC, Dupuis J, Barroso I, Morris AP, Prokopenko I, Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), many others. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nature Communications. 2021;12:24, Open Access
DOI: 10.1038/s41467-020-19366-9
Supplementary Materials (zip file)
Li-Gao R, Boomsma DI, Geus EJC de, Denollet J, Kupper HM. The Heritability of Type D Personality by an Extended Twin-Pedigree Analysis in the Netherlands Twin Register. Behavior Genetics. 2021;51(1):1-11, Open Access
DOI: 10.1007/s10519-020-10023-x
Supplementary Materials (zip file)
Maas SCE, Vidaki A, Teumer A, Costeira R, Wilson R, Dongen J van, Beekman M, Völker U, Grabe HJ, Kunze S, Ladwig KH, Meurs JBJ van, Uitterlinden AG, Voortman T, Boomsma DI, Slagboom PE, Heemst D van, Kallen CJH van der, Berg LH van den, Waldenberger M, Völzke H, Peters A, Bell JT, Arfan Ikram M, Ghanbari M, Kayser M. Validating biomarkers and models for epigenetic inference of alcohol consumption from blood. Clinical Epigenetics. 2021;13:198
DOI: 10.1186/s13148-021-01186-3
Supplementary Materials (zip file)
Martin J, Asjadi K, Hubbard L, Kendall K, Pardiñas AF, Boomsma DI, Hamilton SP, Lucae S, Magnusson PK, Martin NG, Abdellaoui A, Dolan CV, Hottenga JJ, Mbarek H, Middeldorp CM, Nivard MG, Willemsen G, Geus EJC de, many others for the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression. PLOS ONE. 2021;16(9):e0248254
DOI: 10.1371/journal.pone.0248254
Supplementary Material (zip file)
McCartney DL, Min JL, Richmond RC, Lu AT, Sobczyk MK, Zee MD van der, The Genetics of DNA Methylation Consortium, Geus EJC de, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dongen J van, Boomsma DI, Waldenberger M, Deary IJ, Relton CL, Horvath S, Marioni RE, many others. Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging. Genome Biology. 2021;22:194, Open Access
DOI: 10.1186/s13059-021-02398-9
Supplementary Materials (zip file)
Melhuish Beaupre LM, Tiwari AK, Gonçalves VF, Zai CC, Marshe VS, Boomsma DI, Penninx BWJH, Milaneschi Y, Shyn SI, Geus EJC de, Willemsen G, Brown GM, Kennedy JL and others for the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder: A Polygenic Risk Score Analysis. Frontiers in Psychiatry. 2021;12:734077, Open Access
DOI: 10.3389/fpsyt.2021.734077
Supplementary Materials (zip file)
Mills MC, Tropf FC, Brazel DM, Zuydam N van, Vaez A, eQTLGen Consortium, BIOS Consortium, Human Reproductive Behaviour Consortium, Boomsma DI, Jansen R, Nivard MG, Penninx BWJH, Dongen J van, Pool R, Hottenga JJ, Geus EJC de, Mbarek H, Willemsen G, Pers TH, Snieder H, Perry JRB, Ong KK, Hoed M den, Barban N, Day FR. Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour. Nature Human Behaviour. 2021;5(12):1717-1730
DOI: 10.1038/s41562-021-01135-3
Supplementary Materials (zip file)
Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Dongen J van, Hottenga JJ, Willemsen G, BIOS Consortium, Wray NR, Beekman M, Slagboom PE, Davies GE, Geus EJC de, Boomsma DI, Vonk JM, Spector TD, Visscher PM, Gaunt TR, Bell JT, Heijmans BT, Mill J, Relton CL, many others. Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nature Genetics. 2021;53(9):1311-1321
DOI: 10.1038/s41588-021-00923-x
Supplementary Materials (zip file)
Minică CC, Neale MC, Boomsma DI, Dongen J van. Combining twin-family designs with measured genetic variants to study the causes of epigenetic variation. Chapter in Translational Epigenetics, Volume 27: Twin and Family Studies of Epigenetics. Edited by Li & Hopper. Academic Press, 2021
Munn-Chernoff MA, Johnson EC, Chou YL, Coleman JRI, Thornton LM, Walters RK, Yilmaz Z, Baker JH, Hübel C, Gordon S, Medland SE, Lin BD, Slagboom PE, Slof-Op't Landt MCT, Hottenga JJ, Ligthart L, Mbarek H, Boomsma DI, Penninx BWJH, Heath AC, Montgomery GW, Martin NG, Sullivan PF, Kaprio J, Breen G, Gelernter J, Edenberg HJ, Bulik CM, Agrawal A, many others. Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addiction Biology. 2021;26(1):e12880
DOI: 10.1111/adb.12880
Supplementary Materials (zip file)
Odintsova VV, Rebattu V, Hagenbeek FA, Pool R, Beck JJ, Ehli EA, Beijsterveldt CEM van, Ligthart L, Willemsen G, Geus EJC de, Hottenga JJ, Boomsma DI, Dongen J van, on behalf of BIOS consortium. Predicting Complex Traits and Exposures From Polygenic Scores and Blood and Buccal DNA Methylation Profiles. Frontiers in Psychiatry. 2021;12:688464, Open Access
DOI: 10.3389/fpsyt.2021.688464
Supplementary Materials (zip file)
Pellegrino-Coppola D, Claringbould A, Stutvoet M, BIOS Consortium, Boomsma DI, Pool R, Dongen J van, Hottenga JJ, Arfan Ikram M, Slagboom PE, Westra HJ, Franke L. Correction for both common and rare cell types in blood is important to identify genes that correlate with age. BMC Genomics. 2021;22:184, Open Access
DOI: 10.1186/s12864-020-07344-w
Supplementary Materials (zip file)
Pistis G, Milaneschi Y, Vandeleur CL, Lasserre AM, Penninx BWJH, Lamers F, Boomsma DI, Hottenga JJ, Marques-Vidal P, Vollenweider P, Waeber G, Aubry JM, Preisig M, Kutalik Z. Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts. Translational Psychiatry. 2021;11:96, Open Access
DOI: 10.1038/s41398-021-01236-7
Supplementary Materials (zip file)
Ruth KS, Day FR, Hussain J, Martínez-Marchal A, Aiken CE, Boomsma DI, Geus EJC de, Hottenga JJ, Mbarek H, Willemsen G, Biobank-based Integrative Omics Study (BIOS) Consortium, eQTLGen Consortium, The Biobank Japan Project, China Kadoorie Biobank Collaborative Group, kConFab Investigators, The LifeLines Cohort Study, The InterAct consortium, 23andMe Research Team, Ong KK, Hoffmann ER, Murray A, Roig I, Perry JRB, many others. Genetic insights into biological mechanisms governing human ovarian ageing. Nature. 2021;596(7872):393-397
DOI: 10.1038/s41586-021-03779-7
Supplementary Materials (zip file)
Silventoinen K, Bogl LH, Jelenkovic A, Vuoksimaa E, Latvala A, Willemsen G, Bartels M, Beijsterveldt CEM van, Siribaddana SH, Rose RJ, Sørensen TIA, DI Boomsma, Kaprio J, many others. Educational attainment of same-sex and opposite-sex dizygotic twins: An individual-level pooled study of 19 twin cohorts. Hormones and Behavior. 2021;136:105054, Open Access
DOI: 10.1016/j.yhbeh.2021.105054
Slob EMA, Brew BK, Vijverberg SJH, Dijs T, Beijsterveldt CEM van, Koppelman GH, Bartels M, Dolan CV, Larsson H, Lundström S, Lichtenstein P, Gong T, Maitland-van der Zee AH, Kraneveld AD, Almqvist C, Boomsma DI. Early-life antibiotic use and risk of attention-deficit hyperactivity disorder and autism spectrum disorder: results of a discordant twin study. International Journal of Epidemiology. 2021;50(2):475-484, Open Access
DOI: 10.1093/ije/dyaa168
Supplementary Materials (zip file)
Smit DJA, Andreassen OA, Boomsma DI, Burwell SJ, Chorlian DB, Geus EJC de, Elvsåshagen T, Gordon RL, Harper J, Hegerl U, Hensch T, Iacono WG, Jawinski P, Jönsson EG, Luykx JJ, Magne CL, Malone SM, Medland SE, Meyers JL, Moberget T, Porjesz B, Sander C, Sisodiya SM, Thompson PM, Beijsterveldt CEM van, Dellen E van, Via M, Wright MJ. Large-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity. Brain and Behavior. 2021;11(8):e02188, Open Access
DOI: 10.1002/brb3.2188
Supplementary Materials (zip file)
Sønderby IE, Meer D van der, Moreau C, Kaufmann T, Bragi Walters G, Abdellaoui A, Boomsma DI, Brouwer RM, Geus EJC de, Hottenga JJ, Hulshoff Pol HE, Ent D van 't, Stefansson H, Stefansson K, Jacquemont S, Thompson PM, Andreassen OA, many others for the ENIGMA-CNV Working Group, ENIGMA 22q11.2 Deletion Syndrome Working Group. 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Translational Psychiatry. 2021;11:182, Open Access
DOI: 10.1038/s41398-021-01213-0
Supplementary Materials (zip file)
Tamimy Z, Kevenaar ST, Hottenga JJ, Hunter MD, Zeeuw EL de, Neale MC, Beijsterveldt CEM van, Dolan CV, Bergen E van, Boomsma DI. Multilevel Twin Models: Geographical Region as a Third Level Variable. Behavior Genetics. 2021;51(3):319-330, Open Access
DOI: 10.1007/s10519-021-10047-x
Veldkamp SAM, Zondervan-Zwijnenburg MAJ, Bergen E van, Barzeva SA, Tamayo-Martinez N, Becht AI, Beijsterveldt CEM van, Meeus W, Branje S, Hillegers MHJ, Oldehinkel AJ, Hoijtink HJA, Boomsma DI, Hartman C. Parental Age in Relation to Offspring’s Neurodevelopment. Journal of Clinical Child & Adolescent Psychology. 2021;50(5):632-644, Open Access
DOI: 10.1080/15374416.2020.1756298
Vermeulen MCM, Heijden KB van der, Kocevska D, Treur JL, Huppertz C, Beijsterveldt CEM van, Boomsma DI, Swaab H, Someren EJW van, Bartels M. Associations of sleep with psychological problems and well-being in adolescence: causality or common genetic predispositions? Journal of Child Psychology and Psychiatry. 2021;62(1):28-39, Open Access
DOI: 10.1111/jcpp.13238
Supplementary Materials (zip file)
Võsa U, Claringbould A, Westra HJ, Bonder MJ, Deelen P, Jansen R, BIOS Consortium; i2QTL Consortium, Nivard MG, Penninx BWJH, Slagboom PE, Dongen J van, Boomsma DI, Scholz M, Powell J, Gibson G, Esko T, Franke L, many others. Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nature Genetics. 2021;53(9):1300-1310
DOI: 10.1038/s41588-021-00913-z
Supplementary Materials (zip file)
Vries LP de, Beijsterveldt CEM van, Maes HH, Colodro-Conde L, Bartels M. Genetic Influences on the Covariance and Genetic Correlations in a Bivariate Twin Model: An Application to Well-Being. Behavior Genetics. 2021;51(3):191-203, Open Access
DOI: 10.1007/s10519-021-10046-y
Supplementary Materials (zip file)
Vries LP de, Baselmans BML, Luykx JJ, Zeeuw EL de, Minică CC, Geus EJC de, Vinkers CH, Bartels M. Genetic evidence for a large overlap and potential bidirectional causal effects between resilience and well-being. Neurobiology of Stress. 2021;14(100315), Open Access
DOI: 10.1016/j.ynstr.2021.100315
Supplementary Materials (zip file)
Vuoksimaa E, Rose RJ, Pulkkinen L, Palviainen T, Rimfeld K, Lundström, Bartels M, Beijsterveldt CEM van, Hendriks A, Zeeuw EL de, Plomin R, Lichtenstein P, Boomsma DI, Kaprio J. Higher aggression is related to poorer academic performance in compulsory education. Journal of Child Psychology and Psychiatry. 2021;62(3):327-338, Open Access
DOI: 10.1111/jcpp.13273
Supplementary Materials (zip file)
Whipp AM, Vuoksimaa E, Korhonen T, Pool R, But A, Ligthart L, Hagenbeek FA, Bartels M, Bogl LH, Pulkkinen L, Rose RJ, Boomsma DI, Kaprio J. Ketone body 3‑hydroxybutyrate as a biomarker of aggression. Nature Scientific Reports. 2021;11(5813), Open Access
DOI: 10.1038/s41598-021-84635-6
Supplementary Materials (zip file)
Whipp AM, Vuoksimaa E, Bolhuis K, Zeeuw EL de, Korhonen T, Mauri M, Pulkkinen L, Rimfeld K, Rose RJ, Beijsterveldt CEM van, Bartels M, Plomin R, Tiemeier H, Kaprio J, Boomsma DI. Teacher-rated aggression and co-occurring behaviors and emotional problems among schoolchildren in four population-based European cohorts. PLoS One. 2021;16(4):e0238667
DOI: 10.1371/journal.pone.0238667
Supplementary Materials (zip file)
Willemsen G, Odintsova VV, Geus EJC de, Boomsma DI. Twin-Singleton Comparisons Across Multiple Domains of Life. Chapter in Twin and Higher-order Pregnancies. Edited by Khalil, Lewi & Lopriore. Springer Nature, 2021
Zeeuw EL de, Voort L, Schoonhoven R, Nivard MG, Emery T, Hottenga JJ, Willemsen G, Dykstra PA, Zarrabi N, Kartopawiro JD, Boomsma DI. Safe linkage of cohort and population-based register data in a genome-wide association study on health care expenditure. Twin Research and Human Genetics. 2021;24(2):103-109
DOI: 10.1017/thg.2021.18
Supplementary Materials (zip file)
Zijlstra H, Bergen E van, Regtvoort A, Jong PF de, Leij A van der. Prevention of reading difficulties in children with and without familial risk: Short- and long-term effects of an early intervention. Journal of Educational Psychology. 2021;113(2):248-267
DOI: 10.1037/edu0000489